Normalizes keratinocyte turnover rate and helps prevent cell hyperproliferation
In a double-blinded, placebo-controlled study, T/Gel® Shampoo with Neutar® Technology demonstrated complete scalp normalization in moderate to severe dandruff and seborrheic dermatitis.1
Prior to treatment
The scalp specimen exhibits parakeratotic cells, intracellular and intercellular lipid droplets, and disordered cellular layers.2
Following treatment with T/Gel® Shampoo
Intracellular lipid droplets are significantly diminished (P<0.001), cell thickness is reduced (P<0.001), and no parakeratosis was observed.2
Coal-tar therapy emerging evidence
Additionally, there is emerging evidence that coal-tar therapy may play a key role in the restoration of epidermal barrier function.1
Coal-tar mediated activation of the aryl hydrocarbon receptor (AHR) signaling pathway may lead to improvement of skin barrier function and increased levels of filaggrin, an essential component in the regulation of epidermal homeostasis1
References
van den Bogaard EH, Bergboer JGM, Vonk-Bergers M, et al. Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest. 2013;123(2):917-927.
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